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Flavopiridol: An antitumor drug with potential application in the treatment of neurodegenerative diseases

Abstract:

Several lines of evidence show that cyclin-dependent kinases (CDKs) contribute to neurodegenerative disorders such as Alzheimer's and Parkinson's diseases, and amyotrophic lateral sclerosis. Given their role in the neuronal apoptosis, the inhibition of CDKs by specific drugs such as flavopiridol may be a valid therapeutic approach. Expression of CDKs was observed in rodent models of excitotoxicity and stroke, and CDK inhibitors showed neuroprotective effects. Flavopiridol may provide significant improvement in neurodegenerative diseases in humans. © 2004 Elsevier Ltd. All rights reserved.

Año de publicación:

2005

Keywords:

    Fuente:

    scopusscopus

    Tipo de documento:

    Article

    Estado:

    Acceso restringido

    Áreas de conocimiento:

    • Cáncer
    • Farmacología

    Áreas temáticas:

    • Farmacología y terapéutica
    • Enfermedades
    • Medicina y salud

    Contribuidores:

    Pallás M.Pallás M.
    Verdaguer E.Verdaguer E.
    Antoni CaminsAntoni Camins
    Canudas A.M.Canudas A.M.
    Jordá E.G.Jordá E.G.
    Jiménez A.Jiménez A.