385 Oral Sildenafil Treatment as an Alternative to Inhaled no Therapy for Persistent Pulmonary Hypertension of the Newborn

Abstract:

Background: Inhaled nitric oxide (iNO) has been successfully used in infants with severe persistent pulmonary hypertension (PPHN). This therapy, however, is expensive and complex and may not be available n developing countries. Sildenafil, a phosphodiesterase inhibitor (PDI) type V, has been shown to selectively reduce pulmonary vascular resistance in both animal models and patients. Weather Sildenafil could be effective as an alternative to iNO therapy in PPHN, is not known. Objective: To compare the efficacy of oral Sildenafil therapy and conventional therapy in neonates with PPHN diagnosis, prospectively. DESIGN/METHODS: Term neonates with PPHN diagnosis and oxygenation index (OI)> 25 were randomly assigned to placebo (n= 11) or to Sildenafil at 2 mg/kg by orogastric tube every 6 h (n= 13). Arterial blood gases, OI, mean airway pressure (MAWP) and mean blood pressure (BP) were …

Año de publicación:

2005

Keywords:

Fuente:

google