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Antileishmanial cyclic peroxides from the palauan sponge Plakortis aff. angulospiculatus

Abstract:

As part of a program to discover new drugs for the treatment of tropical diseases, we have isolated and identified six new metabolites from the Palauan sponge Plakortis aff. angulospiculatus. Two cyclic peroxides show strong in vitro antiproliferative effects on promastigotes of Leishmania mexicana, a flagellate protozoan that causes leishmaniasis. The structures of the cyclic peroxides 1, 2 and 5 and furans 3, 4 and 6 were elucidated by interpretation of spectroscopic data, molecular modelling, and chemical interconversions.

Año de publicación:

1998

Keywords:

    Fuente:

    scopusscopus

    Tipo de documento:

    Article

    Estado:

    Acceso restringido

    Áreas de conocimiento:

    • Farmacología
    • Biotecnología
    • Microbiología

    Áreas temáticas:

    • Microorganismos, hongos y algas
    • Bioquímica

    Contribuidores:

    Compagnone R.S.Compagnone R.S.
    Rangel H.R.Rangel H.R.
    Alírica Isabel SuárezAlírica Isabel Suárez
    Dagger F.Dagger F.
    Piña I.C.Piña I.C.
    Faulkner D.Faulkner D.
    Reddy M.Reddy M.