Antimicrobial activity, vaginal and dermal irritability of aqueous extracts of dry leaves of Solanum americanun Mill.

Abstract:

S. americanum (yerba mora) is used in a traditional way to treat skin ulcers; it is used also as antiinflammatory and antiseptic in skin diseases and in cervicovaginitis. However, there are few preclinical studies validating it. A study was conducted to assess the antimicrobial activity, vaginal and skin irritability of 2 decoctions of dry leaves of S. americanun. Two aqueous extracts were prepared from dry leaves:(a) 20% and the antimicrobial activity was assessed by means of diffusion method in agar against Candida albicans, Escherichia coli, Klebsiella pneumoniae and Salmonella Typhimurium; the irritability in rabbit vagina by Draize method;(b) 30% and the skin irritability by Draize method in rabbits. Using a decoction of dry leaves (20%), a growing inhibition halo of 15.5 mm was achieved with C. albicans. There was a minimal vaginal irritability and no erythema and oedema in skin of animals using a decoction of dry leaves (30%). The decoction of dry leaves showed antimicrobial activity versus C. albicans but not against other microorganisms, with a minimal vaginal irritability, and was classified as non-skin irritant.

Año de publicación:

2009

Keywords:

Fuente:

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