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Antioxidant aryl-prenylcoumarin, flavan-3-ols and flavonoids from Eysenhardtia subcoriacea

Abstract:

Antioxidant activity (AOA) assay-guided chemical analysis, using a rat pancreas homogenate model, of aerial parts from Eysenhardtia subcoriacea, led to isolation of the new compound subcoriacin (3-(2′-hydroxy-4′,5′-methylendioxyphenyl)-6-(3″- hydroxymethyl-4″-hydroxybut-2″-enyl)-7-hydroxycoumarin) together with the known substances: (+)-catechin, (-)-epicatechin, (+)-afzelechin, eriodictyol, (+)-catechin 3-O-β-d-galactopyranoside and quercetin 3-O-β-d-galactopyranoside as bioactive constituents. The structure of the compound was determined from 1D and 2D NMR spectroscopic analyses. Additional known constituents were characterized. The bioactive compounds showed also moderate to strong radical scavenging properties against diphenylpicrylhydrazyl radical (DPPH). In addition, subcoriacin, (+)-catechin, (-)-epicatechin and (+)-afzelechin improved the reduced glutathione levels in rat pancreatic homogenate. © 2007 Elsevier Ltd. All rights reserved.

Año de publicación:

2008

Keywords:

Subcoriacin
Fabaceae
Reduced glutathione
Flavan-3-ols
3-(2′-hydroxy-4′,5′-methylendioxyphenyl)-6-(3″- hydroxymethyl-4″-hydroxybut-2″-enyl)-7-hydroxycoumarin
Antioxidant activity
Eysenhardtia subcoriacea
Coumarins