Functionalization with Interpenetrating Smart Polymer Networks by Gamma Irradiation for Loading and Delivery of Drugs

Abstract:

Polymer modification (at the surface or in the bulk matrix) has been a significant issue over two decades in many fields of application. Among functionalization techniques developed to date, the grafting method by gamma irradiation has emerged as a useful and versatile approach to improve properties of polymer materials for a wide variety of biomedical applications. Developments in the fields of implants and controlled drug delivery systems have promoted the need to add new properties such as grafting of pH- and/or temperature-responsive polymers with the capability to adsorb therapeutic substances and to control its release rate for prevention of the development of biofilm-related infections and inflammatory reactions. This chapter revises some advances in the preparation by gamma irradiation of graft copolymers containing interpenetrating polymer networks (IPNs) and other architectures, mainly focusing on the performance of materials modified with stimuli-responsive (smart) components.

Año de publicación:

2013

Keywords:

• Drug delivery systems
• Stimuli-sentive polymers
• grafting
• Implantable polymers
• IPNs
• Gamma irradiation

Fuente:

scopus