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Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population

Abstract:

To test whether African ancestry is protective for severe dengue, we genotyped 49 hospitalized cases of dengue hemorrhagic fever (DHF) as well as 293 neighborhood cases of dengue fever and 294 asymptomatic controls in Salvador, Bahia, Brazil. Ancestry-informative markers and 282 unlinked SNPs not associated with the clinical presentation of dengue were used to estimate ancestry. After controlling for income, both self-defined Afro-Brazilian ethnicity and African ancestry were protective for DHF (P=0.02, OR=0.28 and P=0.02, OR=0.13, respectively). Income or an index of income indicators, however, was also independently associated with the diagnosis of DHF.

Año de publicación:

2008

Keywords:

    Fuente:

    scopusscopus

    Tipo de documento:

    Article

    Estado:

    Acceso abierto

    Áreas de conocimiento:

    • Epidemiología
    • Epidemiología

    Áreas temáticas:

    • Medicina forense; incidencia de enfermedades
    • Bioquímica
    • Problemas sociales y servicios a grupos

    Contribuidores:

    Reis E.A.G.Reis E.A.G.
    Silva L.K.Silva L.K.
    Castro J.M.Castro J.M.
    Vasconcelos P.F.d.C.Vasconcelos P.F.d.C.
    Mauricio L. BarretoMauricio L. Barreto
    Teixeira Md M.d.G.Teixeira Md M.d.G.
    Nunes M.R.T.Nunes M.R.T.
    Melo P.S.Melo P.S.
    Blanton R.E.Blanton R.E.
    Goddard K.A.B.Goddard K.A.B.
    Rodrigues S.G.Rodrigues S.G.
    Parrado A.R.Parrado A.R.
    Dias J.P.Dias J.P.
    Reis M.G.Reis M.G.
    Morato V.G.Morato V.G.