Genetic factors involved in susceptibility for developing Parkinson's disease

Abstract:

Parkinson's disease (PD) is the main cause of parkinsonism (rigidity, resting tremor, bradykinesia and loss of postural reflexes). There is evidence highlighting the importance of the interaction between environmental factors and genetics on the pathogenesis of PD. The research about the role of genetics in Parkinson's disease began with familial aggregation studies, which have shown that approximately 10-15% of patients with PD have a positive first-degree family history of PD; this proportion is higher than a 1% found in controls. Twins studies have found a larger concordance rate in monozygotic twins with early-onset PD (symptoms onset before 40 years of age). Nevertheless, dopaminergic functional studies in twins using PET (Positron Emission Tomography) with [F-18]dopa have also shown a substantial role for inheritance in late-onset, sporadic PD. In one of these studies with clinically discordant twins …

Año de publicación:

2007

Keywords:

Fuente:

google