Genomic epidemiology of SARS-CoV-2 transmission lineages in Ecuador
Abstract:
Characterisation of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genetic diversity through space and time can reveal trends in virus importation and domestic circulation and permit the exploration of questions regarding the early transmission dynamics. Here, we present a detailed description of SARS-CoV-2 genomic epidemiology in Ecuador, one of the hardest hit countries during the early stages of the coronavirus-19 pandemic. We generated and analysed 160 whole genome sequences sampled from all provinces of Ecuador in 2020. Molecular clock and phylogeographic analysis of these sequences in the context of global SARS-CoV-2 diversity enable us to identify and characterise individual transmission lineages within Ecuador, explore their spatiotemporal distributions, and consider their introduction and domestic circulation. Our results reveal a pattern of multiple international importations across the country, with apparent differences between key provinces. Transmission lineages were mostly introduced before the implementation of non-pharmaceutical interventions, with differential degrees of persistence and national dissemination.
Año de publicación:
2021
Keywords:
- Phylogeography
- phylogenetics
- Molecular epidemiology
- SARS-COV-2
- Transmission lineages
Fuente:


Tipo de documento:
Article
Estado:
Acceso abierto
Áreas de conocimiento:
- Epidemiología
- Epidemiología
- Microbiología
Áreas temáticas:
- Enfermedades
Contribuidores:


































