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Genomic epidemiology of azithromycin-nonsusceptible neisseria gonorrhoeae, Argentina, 2005-2019

Abstract:

Azithromycin-nonsusceptible Neisseria gonorrhoeae strains are an emerging global public health threat. During 2015-2018, the prevalence of azithromycin-nonsusceptible gonococcal infection increased significantly in Argentina. To investigate the genomic epidemiology and resistance mechanisms of these strains, we sequenced 96 nonsusceptible isolates collected in Argentina during 2005-2019. Phylogenomic analysis revealed 2 main clades, which were characterized by a limited geographic distribution, circulating during January 2015-November 2019. These clades included the internationally spreading multilocus sequence types (STs) 1580 and 9363. The ST1580 isolates, which had MICs of 2-4 μg/mL, had mutations in the 23S rRNA. The ST9363 isolates, which had MICs of 2-4 or ≥256 μg/mL, had mutations in the 23S rRNA, a mosaic mtr locus, or both. Identifying the geographic dissemination and characteristics of these predominant clones will guide public health policies to control the spread of azithromycin-nonsusceptible N. gonorrhoeae in Argentina.

Año de publicación:

2021

Keywords:

    Fuente:

    scopusscopus

    Tipo de documento:

    Article

    Estado:

    Acceso abierto

    Áreas de conocimiento:

    • Epidemiología
    • Epidemiología

    Áreas temáticas:

    • Fisiología humana
    • Enfermedades
    • Medicina forense; incidencia de enfermedades

    Contribuidores:

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    Yoya N.Yoya N.
    Pato R.Pato R.
    Casanova N.Casanova N.
    Morales M.Morales M.
    Cardozo L.Cardozo L.
    Sparo M.Sparo M.
    Cervetto M.Cervetto M.
    Roncallo M.Roncallo M.
    Berejnoi A.Berejnoi A.
    Lopez A.C.Lopez A.C.
    Tuduri E.Tuduri E.
    Pereyra A.Pereyra A.
    Cristaldo P.Cristaldo P.
    Cudmani N.Cudmani N.
    Ranea P.Ranea P.
    Unemo M.Unemo M.
    Mariñasqui O.Mariñasqui O.
    Alfonso C.Alfonso C.
    Giovanakis M.Giovanakis M.
    Bello Velázquez G.Bello Velázquez G.
    Tarzia A.Tarzia A.
    Tognieri A.Tognieri A.
    Prestifilippo A.Prestifilippo A.
    Krause W.Krause W.
    Mernes M.Mernes M.
    Manuel V. GónzalezManuel V. Gónzalez
    Lopez A.Lopez A.
    Poklepovich T.Poklepovich T.
    Turco M.Turco M.
    Garbaz C.Garbaz C.
    Odriz S.Odriz S.
    Sponton N.Sponton N.
    Ampuero F.Ampuero F.
    Solís H.Solís H.
    Vilches V.Vilches V.
    Moreno L.Moreno L.
    Rivollier G.Rivollier G.
    Burzla A.Burzla A.
    Scarone N.Scarone N.
    Campos J.Campos J.
    Roginski S.Roginski S.
    Flores M.Flores M.
    Simone P.Simone P.
    Gianecini R.A.Gianecini R.A.
    Lopez T.Lopez T.
    Sly G.Sly G.
    Fernández Canigia L.Fernández Canigia L.
    Montoto M.Montoto M.
    Alvarez M.Alvarez M.
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    Machain M.Machain M.
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    Valles J.Valles J.
    Marcato M.Marcato M.
    Basco L.Basco L.
    Rizzo M.Rizzo M.
    Manías V.Manías V.
    Pereyra N.Pereyra N.
    Galarza P.Galarza P.
    Vargas M.Vargas M.
    Oviedo C.Oviedo C.
    Spadaccini L.Spadaccini L.
    Scocozza L.Scocozza L.
    Guillermel V.Guillermel V.
    Garrone M.Garrone M.
    Smayevski J.Smayevski J.
    Brihuela A.Brihuela A.
    Prieto N.Prieto N.
    Bandoni C.Bandoni C.
    Golparian D.Golparian D.