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Growth factors in monoclonal light-chain-related renal diseases

Abstract:

The immunomorphological expressions of monoclonal light-chain-related renal diseases (MLCRRD) are extremely varied but have a common pathogenetic feature: monoclonal light-chain deposition. The underlying cellular events involved in these processes are likely a reflection of interactions of a complex cascade of inciting and modulating factors. This study explored the potential role of growth factors in MLCRRD by examining the expression of insulin-like growth factor (IGF-I), fibroblast growth factor (FGF), transforming growth factor-beta (TGF-β), and platelet-derived growth factor A chain (PDGF-A) and B chain (PDGF-B) in 36 cases of MLCRRD. All growth factors examined were expressed in tubules, primarily proximal, but to varying extent. Intensity of IGF-I and TGF-β tubular staining correlated with tubular injury and interstitial fibrosis. Intensity of tubular staining with antibodies to FGF also correlated with …