Growth inhibition of Trypanosoma cruzi and Leishmania donovani infantum by different snake venoms: Preliminary identification of proteins from Cerastes cerastes venom which interact with the parasites

Abstract:

Venom from three different snake species was tested in vitro against the protozoan parasites Trypanosoma cruzi and Leishmania ddonovani infantum. Two of them, Cerastes cerastes and Naja haje, exerted a significant growth inhibition of T. cruzi and L. d. infantum parasites. Heating of the venoms abolished their activity, suggesting that the active factors are thermolabile. Incubation of parasites with 125I-labelled C. cerastes venom proteins allowed preliminary identification of components which interact preferentially with the pathogens. © 1994.

Año de publicación:

1994

Keywords:

Fuente:

scopus