HISTOLOGICAL AND MICROBIOLOGICAL EVALUATION IN MICE OF CYANOACRYLATE (HISTOACRYL) AS POSSIBLE REGENERATIVE AGENT TO REPLACE TRADITIONAL SUTURES

Abstract:

Background Traditional sutures, staples and surgical tapes are the most common methods used to close wounds in veterinary patients. However, these methods can induce granuloma and fistulas formation, loose sutures and wound leaks. Lately, tissue adhesives such as cyanoacrylates (Histoacryl®) have become popular, this glue can bond tissues such as endothelium, mucosa, skin, blood and bone rapidly. Studies using cyanoacrylates have shown bond strength, bacteriostatic and hemostatic properties. The objective of this work is to compare the use of n-butyl-cyanoacrylate with non-absorbable sutures in tissue regeneration by histology and microbiological analysis in mice. (All procedures were approved by the USFQ Ethics Committee on Animal Experimentation, Doc# 2020-001). Methods Two cuts of 1 cm were perfomed in the dorsal skin of each mouse: one cut was bonded by simple suture (control), and …

Año de publicación:

2021

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Fuente:

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