HIV-1 seroreversion in an HIV-1-seropositive patient treated during acute infection with highly active antiretroviral therapy and mycophenolate mofetil

Abstract:

Here we describe a case of seroreversion after the start of highly active antiretroviral therapy (HAART) during acute HIV infection, with seronegativity being sustained for almost one year, after which the patient discontinued drug therapy leading to an immediate increase in both the viral load and antibody titre. A Dutch homosexual man developed fever, a sore throat and a skin rash in October 2000. HIV-1 RNA tested positive on 7 November, anti-HIV-1 antibodies were undetectable. Three weeks later, a Western-blot showed reactivity with all categories of HIV-1 antigens, and serology was positive for HIV-1 antibodies, hepatitis A virus IgM and total antibodies, hepatitis B surface and hepatitis B core antibodies, cytomegalovirus IgG, Epstein–Barr virus viral capsid antigen-IgG and anti-Epstein–Barr nuclear antigen. In December 2000, HAART with five drugs (didanosine/lamivudine/abacavir/nevirapine/indinavir and …

Año de publicación:

2004

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