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Abstract:

Cytochrome P450 2D6 (CYP2D6) is involved in the metabolism of many antidepressants. It is characterized by a high individual variability in catalytic activity mainly due to> 75 CYP2D6 alleles that determine metabolizer status. The role of CYP2D6 genetic polymorphism in the metabolism of amitriptyline and fluoxetine was previously demonstrated [LLerena et al, 2004]. Herein, we analyzed the relevance of CYP2D6 genetic polymorphism for the clinical response to the antidepressant drugs fluoxetine and amitriptyline. Sixty-five patients (DSM-IV) diagnosed with major depression and a score equal or greater than 17 on the Hamilton-Depression (HAM-D) were prospectively studied. They were treated either with fluoxetine or amitriptyline under antidepressant monotherapy. The informed written consent was obtained from all patients. Clinical Response was evaluated with HAM-D. The patients were evaluated every …