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Hazardous air pollutants and risk of breast cancer among a cohort of California teachers

Abstract:

Background: While numerous hazardous air contaminants, many with widespread human exposure potential, have been shown to cause mammary tumors in animals, there is a dearth of human health evidence. Aims: The objective of this analysis was to estimate the risk of breast cancer associated with residential exposures to hazardous air pollutants (HAPs) in a large prospective study of female California teachers. Methods: The study population consisted of 112,380 members of the California Teachers Study (CTS) who had no prior history of breast cancer and lived at a geocoded California address at the initiation of the study in 1995. 5,025 cases of invasive breast cancer diagnosed 1996-2009 were identified through annual linkages to the California Cancer Registry. Estimated levels of HAPs were obtained from the U.S. EPA’s 2002 NATA database and assigned to study participants’ baseline addresses based …