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Health-related quality of life and fatigue in HIV-1 infected patients diagnosed during primary versus chronic infection

Abstract:

Background Health-related quality of life (HRQOL) is affected by chronic HIV-infection (CHI). No data are available if and to what extent HRQOL is affected in patients who were diagnosed during primary HIV-1 infection (PHI). Methods Included were Dutch, male, adult, HIV-1 infected patients, attending the AMC outpatient clinic who seroconverted after December 31st of 1996. 59 Patients identified during PHI and a randomly selected group of 99 patients that were identified with CHI in the same period were eligible. Patients were excluded if they ever had an CDC-C event or suffered any significant comorbidity. Subjects were asked to complete the SF-36 and the Multidimensional Fatigue Inventory (MFI-20) questionnaires. SF-36 and MFI-20 scores were compared with age-and gender-matched Dutch or German general population norms, respectively. Results 123 patients were included: 48 from the PHI group and 75 …