40TiP Activity of the addition of progesterone to standard EDP-M scheme in patients with advanced adrenocortical carcinoma: A randomized, placebo-controlled phase II trial (PESETA)

Abstract:

Background Standard chemotherapy for advanced AdrenoCortical Carcinoma (ACC), an extremely rare and aggressive neoplasm, is etoposide, doxorubicin, cisplatin in association with oral mitotane (EDP-M). The efficacy of this regimen, however, is limited. Progesterone has demonstrated to exert a cytotoxic effect on ACC cell viability, due to the interaction with its intracellular receptors (PgRs), which are involved in the regulation of ACC cell growth, proliferation, and invasiveness. Wnt/β catenin pathway is a target of progesterone activity. This study will address the hypothesis that megestrol acetate has a potentiating effect to EDP-M in inducing tumor shrinkage in locally advanced/metastatic ACC patients.

Año de publicación:

2023

Keywords:

Fuente:

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