Hexafluoroacetone as protecting and activating reagent. A new approach to N-glycosides

Abstract:

N-Glycosides of Asn and homologues have been synthesized starting from hexafluoroacetone-protected ω-activated Asp, Glu, and Aad derivatives and glycosylamines. The synthetic value of the new building blocks was demonstrated by the concise incorporation of N-glycosylated Asn, Gln, and Aad ω-amides into glycopeptides. © Springer-Verlag 2004.

Año de publicación:

2004

Keywords:

• Dielectrophiles
• N-Glycopeptides
• N-Glycosylamino acids
• Hexafluoroacetone
• N-glycosylation

Fuente:

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scopus