Hexafluoroacetone as protecting and activating reagent: Reactions of hexafluoroacetone with α-keto acids

Abstract:

Hexafluoroacetone and α-keto acids react to give 5,5-bis(trifluoromethyl) substituted 2(5H)-furanones and/or 2,2-bis(trifluoromethyl)-1,3-dioxolan-4-ones depending upon the substituent pattern of the side chain of the acid. A fluoroanalogue of the natural product zymonic acid was obtained from ethyl 3,3,3-trifluoropyruvate and 2-oxosuccinic acid in one step. © 2004 Elsevier B.V. All rights reserved.

Año de publicación:

2004

Keywords:

• Hexafluoroacetone
• Zymonic acid
• 5,5-Bis(trifluoromethyl)-2(5H)-furanones
• α-Keto acids
• 2,2-Bis(trifluoromethyl)-1,3-dioxolan-4-ones
• 5-Trifluoromethyl-2(5H)-furanones
• Butenolides

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