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High incidence of Y-chromosome microdeletions in gonadal tissues from patients with 45,X/46,XY gonadal dysgenesis

Abstract:

A higher incidence of Y-chromosome microdeletions was found on gonadal DNA than on peripheral blood lymphocyte DNA and on streak gonads than on dysgenetic testis in 11 patients with 45,X/46,XY gonadal dysgenesis. It is probable that an association between Y-chromosome microdeletions and severity of the phenotype in 45,X/46,XY patients exists. © 2008 American Society for Reproductive Medicine.

Año de publicación:

2008

Keywords:

    Fuente:

    scopusscopus
    googlegoogle

    Tipo de documento:

    Article

    Estado:

    Acceso restringido

    Áreas de conocimiento:

    • Genética
    • Genética

    Áreas temáticas:

    • Fisiología humana
    • Enfermedades
    • Ginecología, obstetricia, pediatría, geriatría

    Contribuidores:

    Puerta H.Puerta H.
    Francisco Álvarez-NavaFrancisco Álvarez-Nava
    Soto-Quintana M.Soto-Quintana M.
    Pineda L.Pineda L.
    Temponi A.Temponi A.