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Histopathological characterization in the leukoplakia buccalis in Havana during 10 years

Abstract:

The epithelial dysplasia is considered the stronger pbkp_redictor of a future malignant transformation of the leukoplakia buccalis. The aim of present paper was to determine the presence and severity of this type of dysplasia and its association with the histological alterations of epithelial and connective tissues of mucosa in the leukoplakia buccalis. A cross-sectional and descriptive research was conducted in 83 biopsies processed by technique of paraffin inclusion and stained with Hematoxylin and Eosin of patients diagnosed with this entity between 1991-2001 from the Stomatology Faculty of the Medical Sciences University of La Habana. The 92.8 % of patients with a clinical diagnosis of leukoplakia buccalis had slight epithelial dysplasia, from these and according to its grade of severity, there was found a slight epithelial dysplasia in the 53.0 %, moderate epithelial dysplasia in the 36.4 % and a severe epithelial dysplasia in 10.4 %. The parakeratosis was manifested in the 43.9 % associated with a slight epithelial dysplasia, 78.6 % with a moderate dysplasia and in the 100% with the severe one. The epithelial dysplasia was present in the 57.1 % of cases and the inflammatory infiltrate in the 79.2 % of study samples. Authors conclude that in the study sample of leukoplakia buccalis there is a high percentage of epithelial dysplasia with predominance of its slight degree and a association between its severity degree with the different patterns of keratinization and the intensity of inflammatory infiltrate, something important in the analysis of its course in face a determined diagnosis y its prognosis.