Homologation of α-hydroxy acids to α-unsubstituted β-hydroxy carboxamides via Arndt-Eistert reaction

Abstract:

Here we studied the homologation of leucic and phenyl lactic acid via Wolff-rearrangement of their diazoketones to the corresponding β-hydroxy acids. This reaction requires distinct conditions to that of their amino acid analogues. The choice of the Oα-substituent can selectively direct the reaction to α-unsubstituted β-hydroxy carboxamides or (E)-α,β-unsaturated carboxamides and offers a new route from α-hydroxy acids to such compounds. © 2006 Elsevier Ltd. All rights reserved.

Año de publicación:

2006

Keywords:

• α,β-Unsaturated carboxylic acids
• α-Hydroxy diazoketones
• Microwave shock-heating
• β-Hydroxy carboxylic acids

Fuente:

scopus

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