Hormonal regulation of B-cell function and systemic lupus erythematosus

Abstract:

The prevalence of systemic lupus erythematosus (SLE) is far higher in females than in males and numerous investigations to understand this gender bias have been performed, which propose as casual actors genetic pbkp_redispositions and sex hormones effects. We will describe in this review how the sex hormones estrogen and prolactin influence B cell maturation and selection, permitting B cells to mature to immunocompetence in a mouse model of lupus. Finally, we will discuss the relevance and implications of these results for human disease. © 2008 SAGE Publications Los Angeles.

Año de publicación:

2008

Keywords:

• prolactin
• Mouse model
• Oestrogen
• Auto antibodies
• B cells

Fuente:

scopus