Regresar

Hormonal signaling factors produced by brown adipose tissue as regulators of metabolism of carbohydrates and lipids

Abstract:

Brown adipose tissue is one of the principal generators of heat in the body; due to the activation of many hormones and receptors, it takes a fundamental role in thermogenesis. However recent studies have proved that this is not its only function. Brown adipose tissue could also act as an endocrine organ, which means that it releases chemical substances to the blood and regulate some activities in the organism. This cell communication process is momentous, since allowing cells to exchange physicochemical information with the environment and other cells in the body could be a relevant field of study in treatments of obesity, diabetes and other diseases related with body weight. This paper offers an overview of different transcriptional factors, endocrine regulation and therapeutic applications of the brown fat tissue, and also the distinctions that it has with white adipose tissue and beige adipose tissue.