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How dormant is Mycobacterium tuberculosis during latency? A study integrating genomics and molecular epidemiology

Abstract:

Mycobacterium tuberculosis may survive for decades in the human body in a state termed latent tuberculosis infection (LTBI). We investigated the occurrence during LTBI of insertion/deletion events in a selected set of mononucleotide simple sequence repeats, DNA sequence changes in four M. tuberculosis genes, and large sequence variations in 4750 M. tuberculosis open reading frames. We studied 13 paired M. tuberculosis clinical isolates, with each pair representing a reactivation of LTBI more than three decades after primary infection. Absence of sequence variations between paired isolates in nearly all investigated loci suggests a low likelihood of bacterial replication during LTBI. © 2011 Elsevier B.V.

Año de publicación:

2011

Keywords:

  • Genomics
  • Molecular epidemiology
  • Latent tuberculosis infection

Fuente:

scopusscopus

Tipo de documento:

Article

Estado:

Acceso restringido

Áreas de conocimiento:

  • Biología molecular
  • Infección

Áreas temáticas:

  • Enfermedades

Contribuidores:

Andersen A.B.Andersen A.B.
Thomsen V.Ø.Thomsen V.Ø.
Lixin ZhangLixin Zhang
Carl F. MarrsCarl F. Marrs
Yang Z.H.Yang Z.H.
Rosenberg N.A.Rosenberg N.A.
Lillebaek T.Lillebaek T.
Talarico S.Talarico S.
Rosenthal M.Rosenthal M.