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Human Interleukin 2: Production by Both TG Cells and Other T Cells

Abstract:

We have investigated the production of interleukin 2 (IL‐2) by human T cells after their stimulation by phytohaemagglutinin (PHA). T cells isolated by rosetting with sheep erythrocytes produced high levels of IL‐2. Further separation of rosette‐forming cells, according to the expression of Fc receptors for IgG, showed that T<inf>G</inf> and non‐T<inf>G</inf> cells are equally able to produce IL‐2. The release of IL‐2 by T<inf>G</inf> cells did not require DNA synthesis or functional Fey receptors, since positively selected T<inf>G</inf> cells produced IL‐2, even though they lacked lymphoproliferative responses to PHA and antibody‐dependent cell‐mediated cytotoxicity. Copyright © 1981, Wiley Blackwell. All rights reserved