Humoral Response against Native Plasmodium berghei Hemozoin and Synthetic Hemozoin in BALB/c Mice

Abstract:

Aims: Malaria is a disease caused by protozoan parasites of the genus Plasmodium. One of the malaria mechanisms of adaptation to the host is the digestion of hemoglobin by the trophozoite stage. This mechanism provides the amino acids needed by the parasite and is carried out during the erythrocytics schozogony phase, which results in the formation of in soluble pigment crystals named hemozoin (Hz). Hz is responsible for many of the immune pathological complications of malaria, given that this pigment accumulates in various organs in severe cases of the disease. Here, we evaluated the humoral response in BALB/c mice against native Plasmodium berghei Hz (PbHz) and synthetic Hz (SHz). Place and Duration of Study: Laboratory of Immunology of Infection Diseases. Department of Cell Biology, Simón Bolívar University, Caracas, Venezuela. This study

Año de publicación:

2014

Keywords:

Fuente:

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