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Hypoglycemic effect of aqueous extract from Chuquiraga jussieui J.F. Gmel in rats with induced diabetes

Abstract:

Introduction: Chuquiraga jussieui J.F. Gmel is a wild plant species that grows in the Ecuadorian Andes. It is broadly used by ancestral cultures and the common population as folk medicine, particularly as antidiabetic, anti-inflammatory and febrifuge. Objectives: Determine the hypoglycemic effect of aqueous extract from Chuquiraga jussieui in rats with induced diabetes. Methods: Determination of the hypoglycemic effect was conducted in rats from the Wistar isogenic line with induced hyperglycemia. Six groups were formed: normal control without treatment, hyperglycemic control with streptozotocin, hyperglycemic control treated with the hypoglycemic drug glibenclamide, and aqueous extract from Chuquiraga jussieui at three concentrations (100, 200 and 400 mg/kg body weight). Statistical assessment of results included normal distribution by the Shapiro–Wilk test, variance homogeneity by Levene's test, analysis of variance between the groups, and multiple comparisons by Tukey's tests.Results: The streptozotocin group with induced hyperglycemia and no treatment showed a significant mean glycemia increase throughout the study. The glibenclamide group showed a significant decrease of over 8 mmol/l, and so did the three extract groups (concentrations of 100, 200 and 400 mg/kg) treated with various volumes of extracts from the study plant, the contrast being greater in the latter group. Conclusions: It was determined that aqueous extract from Chuquiraga jussieui J.F. Gmel displays hypoglycemic activity as of 400 mg/kg versus a drug in a model for type 2 diabetes mellitus.