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INAUGURAL ARTICLE by a Recently Elected Academy Member: A physiologic rise in cytoplasmic calcium ion signal increases pannexin1 channel activity via a C-terminus …

Abstract:

Results The MS-Induced Increase in rPanx1 Channel Activity Depends on the Activation of the Piezo1 Channel and Submembrane Increase in Ca2+ Signal. Since MS has been shown to increase the activity of rPanx1-EGFP (enhanced green fluorescent protein) channels (29, 30) and this response can be mediated by stretch-activated channels, we evaluated changes in MS-induced dye-uptake rate in HeLa rPanx1-EGFP transfectants under pharmacological blockade of different know stretch-sensitive channels, such as MS-activated channels (MSCs) or Piezo1 (27, 28). In DAPI uptake experiments

Año de publicación:

2021

Keywords:

    Fuente:

    googlegoogle

    Tipo de documento:

    Other

    Estado:

    Acceso abierto

    Áreas de conocimiento:

    • Biología celular

    Áreas temáticas:

    • Fisiología humana

    Contribuidores:

    Ximena Miranda LópezXimena Miranda López