Identification of potential anti-aging genes, expression and polymorphisms, coding for mitochondrial related proteins, a systematic literature review (SLR)

Abstract:

Abstracts/Cytotherapy 23 (2021) S17–S207 S157 Background & Aim: Already in the early 90’s, preclinical exploration of IVT mRNA was initiated for various therapeutic applications. The use of mRNA as a therapeutic agent has gained a lot of interest over the last decades as, in contrast to other nucleic acid therapies, the mRNA molecule doesn’t need to enter the target cell’s nucleus and does not integrate into the host genome. Due to these favorable aspects, the field of mRNA-based therapies is rapidly evolving. The potential in various fields, such as cell-and gene therapy, has already been demonstrated in clinical trials. Although the potential of mRNA therapies seems to be endless, purification of mRNA for clinical treatment remains a challenge. Current available methods for mRNA purification become a bottleneck either in large-scale manufacturing or due to other issues such as toxic waste or process …

Año de publicación:

2021

Keywords:

Fuente:

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