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Immune Response to Infection with Strongyloides stercoralis in Patients with Infection and Hyperinfection

Abstract:

Helminthic infections are known to induce host immune responses and polarization. The ubiquitous Strongyloides stercoralis can remain relatively asymptomatic in the host for decades, until there is a change in the host immune balance. Factors that influence these changes range from immunosuppressives, including corticosteroids, to acquired viral infections, such as HTLV-1. These conditions play an important role in the progression of disease for strongyloidiasis. The alteration of the Th-1, Th-2 balance can induce hyperinfection and dissemination of these helminths, changing a minor clinical process to a life-threatening condition.