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Immunological Study of Non Immediate Allergic Reaction to Infliximab

Abstract:

METHODS: The allergological study consisted of patch testing and drug provocation test (DPT) with infliximab at increases doses. The immunological monitorization of the response (T1, T2 and basal) included cellular marker analysis by flow cytometry, skin biopsy and lymphocyte transformation test (LTT) RESULTS: The patch testing were negative with infliximab at 48-72 hours reading in both patients. After DPT with infliximab a maculopapular exanthema was developed in the two patients 24 and 30 hours respectively. The immunological study showed an increase of CD3+ CD4+ lymphocytes with high expression of CXCR3, CLA and CCR10. We observed a strong increase of perforin in both T and NK lymphocytes. These results were confirmed in the skin biopsy obtained after DPT. The LTT showed a CD3+-T-lymphocyte proliferation after infliximab stimulation in the two patients being negative in 10 tolerant …

Año de publicación:

2011

Keywords:

    Fuente:

    googlegoogle

    Tipo de documento:

    Other

    Estado:

    Acceso abierto

    Áreas de conocimiento:

    • Inmunología
    • Inmunología

    Áreas temáticas:

    • Enfermedades

    Contribuidores:

    Eca SinergiaEca Sinergia