Immunoscintigraphy with <sup>99m</sup>Tc-nimotuzumab for planning immunotherapy in patients with bone metastases due to prostate cancer


Abstract:

Detection of bone metastases indicates poor prognosis for patients with prostate cancer. The immunotherapy with monoclonal antibody has been an important advance in the treatment of the cancer in the last years. Nimotuzumab is a humanized IgG1 monoclonal antibody directed against epidermal growth factor receptor that has been evaluated in solid tumors. The authors show images of 2 patients with bone metastases secondary to prostate cancer, "pre-cold therapy" with nimotuzumab. Immunoscintigraphic images were acquired 4 and 24 hours after the intravenous administration of 1110 MBq (30 mCi) of 99mTc-labeled nimotuzumab. Bone metastases expressing the receptor are visualized.

Año de publicación:

2016

Keywords:

  • Immunoscintigraphy
  • nimotuzumab
  • Prostate cancer
  • Monoclonal antibody
  • Bone metastases

Fuente:

scopusscopus

Tipo de documento:

Article

Estado:

Acceso restringido

Áreas de conocimiento:

  • Inmunología

Áreas temáticas:

  • Enfermedades
  • Farmacología y terapéutica