519 Design of a new molecule proven to be safe and effective for topical depigmenting and antiaging method

Abstract:

Skin hyperpigmentation is a biological process that results in an excess production of melanin. Tyrosinase inhibition is an effective approach to this condition, although inhibitors reported in the literature lack clinical efficacy or show toxic effects. Chalcone derivatives are well known tyrosinase inhibitors but insoluble in aqueous phase limiting its use in final product formulations. The aim of this study is to develop a new chalcone-related molecule that is safe and effective as a skin depigmenting and antiaging agent. Homology modelling was used to build the tridimensional structure of human tyrosinase, and virtual docking to pbkp_redict molecule-enzyme binding modes. The efficacy of the designed and synthesised compounds was evaluated in vitro. Tyrosinase activity was assessed spectrophotometrically, and water solubility was determined by HPLC. Cell assays were performed to determine melanin content, toxicity …

Año de publicación:

2022

Keywords:

Fuente:

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