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6-(bromomaleimido)hexanoic acid as a connector for the construction of multiple branched peptide platforms

Abstract:

We report on a novel and user-friendly platform based on a bromomaleimide moiety to obtain branched peptides. The platform is stable for all SPPS conditions. The bromomaleimide core was conjugated to n-copies of thiol-peptide in-solution to obtain two/four/eight-armed dendrimers. Using 2n number of bromomaleimide analogues, 2n ligands were incorporated at both bromo and ene positions via a thioether bond. This method has the advantage of high conversion in a short time, thus enabling effortless purification and characterization processes.

Año de publicación:

2015

Keywords:

    Fuente:

    scopusscopus

    Tipo de documento:

    Article

    Estado:

    Acceso restringido

    Áreas de conocimiento:

    • Péptido
    • Biotecnología
    • Biomateriales

    Áreas temáticas:

    • Ciencias de la computación

    Contribuidores:

    Govender T.Govender T.
    Ramesh S.Ramesh S.
    Alberício F.Alberício F.
    Kruger H.G.Kruger H.G.
    B. G. De la TorreB. G. De la Torre
    Cherkupally P.Cherkupally P.