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744 Genome-Wide Association of Composition and Diversity of the Intestinal Bacterial Phyla in Healthy First Degree Relatives (FDR) of Crohn's Disease (CD) Subjects

Abstract:

(5.0%±5.2). 3,727,707 genetic markers with high quality were imputed. rs2882345, located in a non-coding region of chr 7 was significantly associated with bacterial diversity (p= 4.8× 10-7). No associations were observed among the 163 SNPs associated with IBD. However, a total of 146 SNPs were associated with the relative abundance of microbial phyla (p< 10 6). The strongest signal observed was located on chr 12 with rs145366794 associated with the relative abundance of Firmicutes (p= 6.2× 10-9); however, its minor allele frequency was low (1.6%). SNPs in LINC01446 and CAPRIN1 were associated with the relative abundance of Actinobacteria (p= 5.9× 10-6), SNPs in PHLPP1 and MKL1 were associated with Bacteroidetes (p= 5.9× 10-6 and p= 3.9× 10-6), SNPs in RAB27B and PM20D1 as well as non-coding regions-6 of chr 1 and 18 with Firmicutes (p= 8.0× 10), and SNPs in MET were associated with …