Improved procedures for the synthesis of a N,N-diauyltyrosine intermediates

Abstract:

jV,JV-Diallyltyrosine allyl ester bearing a base-labile phenol protecting group can be obtained from O-benzyloxycarbonyltyrosine by a one-step allylation with allyl bromide. This allyl ester is efficiently deprotected with morpholine in the presence of a catalytic amount of tetrakis(triphenylphosphine)palladium(0) or by alkaline cleavage of the Õ-benzyloxycarbonyl group followed by enzymatic hydrolysis using ¡x-chymotrypsin.

Año de publicación:

1990

Keywords:

Fuente:

scopus