Improving clinical outcomes by reducing bleeding in patients with non-ST-elevation acute coronary syndromes

Abstract:

Aims Bleeding in patients with coronary artery disease has been linked with adverse outcomes. We examined the incidence and outcomes after bleeding in 20 078 patients with acute coronary syndromes (ACS) enrolled in the OASIS-5 trial who were treated with fondaparinux or the low-molecular weight heparin, enoxaparin. Methods and results Nine hundred and ninety (4.9%) patients developed major bleeding and 423 (2.1%) developed minor bleeding. Fondaparinux compared with enoxaparin reduced fatal bleeding [0.07 vs. 0.22%, relative risk (RR) 0.30, 95% CI: 0.13–0.71], non-fatal major bleeding (2.2 vs. 4.2%, RR 0.52, 95% CI: 0.44–0.61), minor bleeding (1.1 vs. 3.2%, RR 0.34, 95% CI: 0.27–0.42), and need for transfusion (1.8 vs. 3.1%, RR 0.56, 95% CI: 0.47–0.61) during the first 9 days. One of every six deaths during the first 30 days occurred in patients who …

Año de publicación:

2009

Keywords:

Fuente:

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