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In Vitro Models of HCC

Abstract:

Liver cancer is a highly heterogeneous disease produced by a variety of risk factors including viral infection and hepatotoxins. The hepatocarcinogenesis process is associated to oxidative stress and takes several steps: initiation, promotion, and progression that have been well characterized in vivo models, such as in protocols with rodents. Also cell culture of human-derived cell lines of liver has been considered of great value as in vitro models for cancer research. Several pharmacological studies with potential antineoplastic and antioxidant compounds have been successfully performed in cultured cell lines because they provide advantages for experimentation with highly reproducible results. The limited treatment options in cancer patients are due to drug resistance and elevated heterogeneity of liver neoplasm; this encourages the investigation of synergistic antineoplastic effect of pharmacological combination with antioxidants in vitro cell models; this may provide additional options for treatment of cancer patients.