In vitro interference of β-lactams with biofilm development by prevalent community respiratory tract isolates

Abstract:

Interference of cefditoren (CDN) and amoxicillin/clavulanic acid (AMC) with biofilm production was studied using 11 Streptococcus pneumoniae isolates with minimum inhibitory concentrations (MICs) ranging from 0.015μg/mL to 0.5μg/mL for CDN and from 0.06μg/mL to 2μg/mL for AMC (except for one isolate with an AMC MIC of 8μg/mL) and 5 Haemophilus influenzae isolates with MICs of 0.03–0.06μg/mL for CDN and 0.5–16μg/mL for AMC. Slime production was assessed in antibiotic-free medium and with 0.03μg/mL CDN or 1/0.5μg/mL AMC by measuring the optical density at 450nm (OD450). Significantly lower mean OD450 values were obtained for S. pneumoniae with antibiotics compared with controls (CDN, 0.088 vs. 0.118, P=0.003; and AMC, 0.095 vs. 0.112, P=0.003), with significant correlation between both antibiotics (r=0.752; P=0.008). Percent reduction in OD450 values was higher for CDN compared …

Año de publicación:

2010

Keywords:

Fuente:

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