In vivoDetection of Colonic Mucosa Microinflammation by Confocal Laser Endomicroscopy Probe (p-CLE) in Patients With Irritable Bowel Syndrome: 2017 Category Award (Functional …

Abstract:

Methods: Prospective, controlled, non-randomized and simple blind study (Jan-2016/Mar-2017), including patients with IBS according to Roma III criteria (IBS group), and healthy patients (control group). Exclusion criteria: patients receiving NSAIDs, corticosteroids or antibiotics, heart, kidney, liver or severe metabolic disease, IBD, bacterial overgrowth, gastrointestinal bleeding, history of colitis, colonic obstruction, colectomy, allergy to fluorescein, pregnancy and poor bowel preparation (Boston Scale< 6). Both groups underwent colonoscopy using p-CLE with target-biopsy of each colorectal section. Altered crypt architecture, epithelial gaps with fluorescein leaks and dilated and prominent branching vessels were the considered p-CLE criterion for inflammation. Following Geboes Scale, biopsies where evaluated by an only pathologist blinded to endoscopic findings. Overall diagnostic accuracy was defined by …

Año de publicación:

2017

Keywords:

Fuente:

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