Increased peripheral α<inf>1</inf>-adrenoceptor sensitivity following chronic thioridazine treatment in the pithed rat

Abstract:

The effect of chronic treatment (10 days) with thioridazine (25 mg/kg per day, i.p.) on the increase in diastolic blood pressure induced by methoxamine and xylazine was studied in the pithed rat. The dose-response curve for methoxamine, but not for xylazine, was shifted to the left by the neuroleptic. These results indicate that postjunctional α1-adrenoceptors in the rat blood vessels become supersentitive after long-term treatment with thioridazine. © 1989.

Año de publicación:

1989

Keywords:

• α -Adrenoceptors 1
• α -Adrenoceptors 2
• Pithed rat
• Thioridazine

Fuente:

scopus