Insulin-resistance in patients with moderate to severe acne

Abstract:

BACKGROUND: Acne is a chronic inflammation of the sebaceous follicle pilo unit that affects more than 40 million people worldwide. It is more common in puberty and young adulthood. Because it is a prevalent disease, there have been numerous studies focusing on finding pathogenic factors; some studies suggest a relationship between insulin levels and the presence of acne. OBJECTIVE: To determine the association between insulin resistance and inflammatory acne of moderate to severe type. MATERIAL AND METHOD: An analytical case-control study was performed from April to June 2016 in a dermatologic private practice in Quito and in the Unidad Educativa Andino in Quito, Ecuador. Young men and women of 16 to 25 years with and without acne were included, and insulin resistance was determined by the index Homeostasis Model Assessment (HOMA-IR) for each individual. RESULTS: Patients with moderate to severe inflammatory acne were diagnosed by dermatologist specialty. Both blood glucose levels (p value > 0.05, 89.5 ± 6.99 vs 88.75 ± 6.58 mg/dL) and insulin (p value > 0.05, 11.60 ± 9.6 vs 9.2 ± 5.43 mU/mL) during fasting had no significant differences between groups of cases and controls. In addition, there was no significant difference between patients with healthy controls in terms of the values of HOMA (p > 0.05, 2.62 ± 2.21 vs 2.04 ± 1.29), but there was correlation between age and HOMA values (p < 0.05). CONCLUSION: The results suggest that insulin resistance does not have a role in the pathogenesis of acne.

Año de publicación:

2018

Keywords:

• Insulin
• Acne
• Insulin Resistance

Fuente:

scopus