Insulinorresistencia en mujeres obesas afrovenezolanas

Abstract:

It has been demonstrated that genetic factors can be influenciated by race, whereas people with African origin tend to have high body mass index (BMI) with normal lipid profile (high HDL-c and low triglyceride). The purpose of this study was to analyze insulin resistance through a mathematical model, Homeostasis Model Assessment (HOMA), in two Venezuelan communities with African origin. Seventy-two afrovenezuelan women from the populations of Santa María (SM) y San José (SJ), Zulia, Venezuela, with age between 36 and 48 years, were used. A medical chart was made along with BMI so that they could be divided into 2 groups: obese and lean; glycemia, lipid profile and HOMA IR were determined. Our results indicated that there was not significative different in glycemia (obese group 85, 1±3, 5 SM y 83±2, 9 SJ; lean 77, 3±2, 2 SM y 78, 9±2, 8 SJ mg/dl), Total Cholesterol (obese group 194, 4±13, 4 SM y 190, 1±9, 1 SJ; lean 184, 4±8.8 SM y 193, 4±7, 4 SJ mg/dl), Triglycerides (obese group 109, 8±16, 3 SM y 114, 8±21, 9 SJ; lean 64, 9±7, 6 SM y 77, 5±10, 8 SJ mg/dl), LDL-c (obese group 126, 6±14, 8 SM y 126, 9±8, 6 SJ; lean 115, 5±8, 3 SM y 133, 6±11, 4 SJ mg/dl) and serics HDL-c (obese group 46, 3±4, 0 SM y 40, 2±3, 4 SJ; lean 55, 5±2, 8 SM y 44, 1±2, 3 SJ mg/dl). When we compared HOMA IR between obese group of both populations (3, 3±0, 2 SM y 3.2±0, 1 SJ) with lean group (2, 8±0, 1 SM y 3, 1±0, 1 SJ) there was not significative difference. In conclusion, the obese women from Santa María and San José have low HDL-c and high HOMA IR.

Año de publicación:

2003

Keywords:

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