Interaction of carbon tetrachloride and progesterone metabolism in liver microsomes from triacetyloleandomycin-treated rats

Abstract:

The production of progesterone metabolites by rat liver microsomes from TAO-treated rats was investigated. More than ten metabolites could be identified, including various dihydroxy-progesterones. CCl4 co-incubation modifies the P-450-dependent progesterone metabolite profile in a remarkable fashion without production of CCl4 progesterone adducts. © 1987 Springer-Verlag.

Año de publicación:

1987

Keywords:

• TAO
• Cytochrome P-450
• progesterone
• CCl 4

Fuente:

scopus