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Interactome of pbkp_redisposition and resistance to SARS-CoV-2. Proteins, genes, and functions

Abstract:

The SARS-CoV-2 infection has been reported to have at least three aspects: the pathogenic capacity of the virus, susceptibility, and virus-host interactions. For several viruses, it has been demonstrated that they have specific cell-binding receptors and are determinant in whether or not the virus enters the cells. For the SARS-CoV-2 virus, the ACE2 receptor (Angiotensin Converting Enzyme 2) is known to be critical for the virus to adhere to the cell membrane of the lung epithelium, the pneumocyte. The ACE2 receptor has its specific gene with the same name on the Xp22.2 chromosome and has interactions with some genes. We set out to find protein interactions related to the entry, symptomatology, and progress of COVID-19 and other similar or adjuvant proteins. These interactions are fundamental to understanding the disease's physiopathology and the different degrees of affectation observed asymptomatic, mild, moderate, severe, and critical, known as clinical heterogeneity. The heterogeneity in the symptoms is likely to reflect the heterogeneity of protein interactions related to the infection by the virus COVID-19 and its correlation between them. The final goal is to find the genes that command these protein interactions and associate them with a clinical variation. This is an initial study of protein interaction to continue with analyzing specific proteins and their variants in the Ecuadorian population.