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Isolation of a new foamy retrovirus from orangutans

Abstract:

We have isolated a new foamy virus from blood samples taken from two apparently healthy orangutans (Pongo pygmaeus). The older orangutan has since died with encephalopathy after a brief acute illness, while the younger one, his grandson, remains well. These animals and 12 other orangutans had specific antibodies to foamy virus as measured by immunofluorescence. The new foamy virus and the antisera showed strong and specific neutralization, with only weak cross-reaction with other simian foamy virus strains. Southern blotting with gag and env probes of human foamy virus and PCR amplification showed that the new foamy virus, designated SFV-11, is related to, yet distinct from, previously characterized strains from humans, chimpanzees, and monkeys.

Año de publicación:

1994

Keywords:

    Fuente:

    scopusscopus

    Tipo de documento:

    Article

    Estado:

    Acceso restringido

    Áreas de conocimiento:

    • Virus

    Áreas temáticas:

    • Medicina forense; incidencia de enfermedades
    • Bioquímica
    • Mammalia

    Contribuidores:

    Aguzzi A.Aguzzi A.
    McClure M.O.McClure M.O.
    Andrew Alexander CunninghamAndrew Alexander Cunningham
    Schulz T.F.Schulz T.F.
    Bieniasz P.D.Bieniasz P.D.
    Chrystie I.L.Chrystie I.L.
    Weiss R.A.Weiss R.A.
    Kirkwood J.K.Kirkwood J.K.
    Simpson G.Simpson G.
    Hoad J.G.Hoad J.G.