Isolation of a novel cytotoxic polyacetylene from a traditional anthelmintic medicinal plant, minquartia guianensis

Abstract:

The stem bark of Minquartia guianensis is used by the Quijos Quichua people of Ecuador's Amazonian lowlands in an infusion drunk to treat intestinal parasitic infections, lung cancer, and tuberculosis and is applied topically to treat muscular pain and skin irritations. Using the in vitro P-388 murine lymphocytic leukemia cytotoxicity bioassay to guide fractionation of the CHC13extract of M, guianensis stem bark, the novel cytotoxic polyacetylene (—)-17-hydroxy-9,11,13,15-octadecatetraynoic acid [1] was isolated. The P-388 ED50of the pure compound is 0.18 μg/ml, and it is also active in the brine shrimp larvicidal bioassay, with an LC50of 5.06 μg/ml (95% confidence interval 3.68—6.98). These biological activities could account for the alleged efficacy of the plant in folk usage. © 1989, American Chemical Society. All rights reserved.

Año de publicación:

1989

Keywords:

Fuente:

scopus