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Kaposi's Sarcoma and Human Herpesvirus 8 in Cuba: Evidence of subtype B expansion

Abstract:

Objective: To evaluate the temporal distribution (1991-2009) and associated variation of KSHV subtypes in Cuba. Method: Phylogenetic characterization based on the KSHV K1 gene was performed using 90 KSHV positive samples. Results: Molecular characterization confirmed the prevalence of a wide range of KSHV subtypes (A: n=48 [A5=12]; C: n=15; B: n=22; and E: n=5). In the current study, we observed a significant increase in HHV-8 subtype B after 2004 (p=0.0063). This Subtype B in Cuba was associated with: heterosexual behaviour (OR: 3.63, CI: 1,2-10,98; p=0.03), with the antecedent of acquiring HIV/KSHV in Africa (p=0.0003), with nodular stage of KS lesions (OR 4.2, CI: 1.1 to 15.7; p=0.04). Conclusion: Our study is the first to report KSHV Subtype B expansion in Cuba, that might be reflective of a change in human behavioural pattern. © 2012 Elsevier Inc.